Piotr Anderszewski is regarded as one of the outstanding musicians of his generation.

He appears regularly in recital at such concert halls as the Wiener Konzerthaus, Berlin Philharmonie, Wigmore Hall, Carnegie Hall, Théâtre des Champs-Élysées and the Concertgebouw Amsterdam. His collaborations with orchestra have included appearances with the Berlin Philharmonic and Berlin Staatskapelle orchestras, the London Symphony and Philharmonia orchestras and the NHK Symphony Orchestra. He has also placed special emphasis on playing and directing, working with orchestras such as the Scottish Chamber Orchestra, Chamber Orchestra of Europe and Camerata Salzburg.

Piotr Anderszewski has been an exclusive artist with Warner Classics/Erato (previously Virgin Classics) since 2000. His first recording for the label was Beethoven's Diabelli Variations, which went on to receive a number of prizes. He has also recorded Grammy-nominated discs of Bach's Partitas 1, 3 and 6 and Szymanowski's solo piano works, the latter also receiving a Gramophone award in 2006. His recording devoted to works by Robert Schumann received the BBC Music Magazine's Recording of the Year award in 2012. Anderszewski's disc of Bach's English Suites nos. 1, 3 and 5, released in November 2014, went on to win both a Gramophone award and an ECHO Klassik award in 2015. His most recent recording featuring a selection of Preludes and Fugues from Bach's Well Tempered Clavier Book II received a Gramophone award in September 2021.

Recognised for the intensity and originality of his interpretations, Piotr Anderszewski has been a recipient of the Gilmore award, the Szymanowski Prize and a Royal Philharmonic Society award.

He has also been the subject of several documentaries by the film maker Bruno Monsaingeon. 'Piotr Anderszewski plays Diabelli Variations' (2001) explores Anderszewski's particular relationship with Beethoven's iconic work. 'Unquiet Traveller' (2008) is an unusual artist portrait, capturing Anderszewski's reflections on music, performance and his Polish-Hungarian roots.

In 2016 Anderszewski got behind the camera himself to explore his relationship with his native Warsaw, creating a film entitled 'Je m'appelle Varsovie'.